CV
E-mail: tlin56@ucla.edu
Education
- B.S. in Biomathematics and Mathematics, Rutgers University, 2016
- M.S. in Biomathematics, University of California, Los Angeles, 2018
- Ph.D in Biomathematics, University of California, Los Angeles, 2021 (expected)
Research experience
- October 2012 – Summer 2013: Experiment Assistant
- CABM Structural Bioinformatics Laboratory (@ Rutgers)
- Duties included: His-tag Chemical Binding Chromatography, using “Cap” method finding protein crystal, primer designing, DNA cloning, and X-ray Crystallography.
- Supervisor: Professor Guy Montelione
- Summer 2013: Undergraduate Research Fellow
- Summer Undergraduate Research Experience (SURE) Program & Byrne Seminar Research Program in CABM (Rutgers)
- Duties included: Focus on solving protein (Enzyme+Coenzyme+Cofactor) structure by crystallization (focus on Crystal structure with enzyme and cofactor), using maltose-binding-protein to increase the solubility of enzyme, Zygosaccharomyces rouxii. ATCC 2623
- Supervisor: Professor Guy Montelione
- Summer 2014: Bernstein Scholarship Research Fellow
- Bernstein Scholarship Summer research in the Center for Integrative Proteomics (Montelione Lab)
- Duties included: Studying and comparing the similarity as well as difference of disorder-region within proteins between protein crystal structure data (through experiments) and software prediction (such as SEG) by using data mining to analyze data from Protein Data Bank (PDB).
- Supervisor: Professor Guy Montelione
- Summer 2014 – November 2015: Team member, Wetlab core member
- BIOMOD competition, Rutgers Team “Nzymes ‘R’ Us”, Khare Lab, Proteomics, Piscataway, NJ
- Duties included: (1) Team Project Website: http://eden.rutgers.edu/~biomod/index.html; (2) Design Primer/Gblock for target PDZ/SH3 domains; (3) Perform Site directed mutagenesis, Amplification, and Gibson Assembly to insert target DNA (DNA for PDZ/SH3 domains) into plamid (pet16 in our case); (4) Express and purify PDZ/SH3 domain proteins; (5) Analyze fluorescent protein mutation impact by using Fluorescent Assay; (6) Completing the Wet lab part of the Project Website (Including Lab protocol, Equipment, and Experimental Status): http://eden.rutgers.edu/~biomod/experiments.html.
- Supervisor: Professor Sagar Khare
- June 2015 – July 2016: Independent interdisciplinary undergraduate researcher
- Honors Interdisciplinary Undergraduate Thesis: Predicting and Enhancing Enzyme Clustering Efficiency, collaboration with Khare Lab & Prof. Eduardo Sontag, Proteomics.
- Duties included: (1) Analyze preliminary research in enzyme scaffolding and enzyme clustering; (2)Create toy model to simulate enzymatic reaction within a cell and change to distribution of enzyme in order to find the optimum enzyme distribution.
- Supervisor: Professor Eduardo Sontag & Sagar Khare
Skills
- Intermediate Skill in X-Ray Crystallography
- Biochemistry and Genetics Lab Operation and Regulation
- Programming:
- Matlab
- R
- Julia
- Python
- Java
Publications
Yang, Lu, Elliott M. Dolan, Sophia K. Tan, Tianyun Lin, Eduardo D. Sontag, and Sagar D. Khare. Computation‐Guided Design of a Stimulus‐Responsive Multienzyme Supramolecular Assembly. ChemBioChem 18, no. 20 (2017): 2000-2006. LINK
Samraat Pawar, Anthony I Dell, Tianyun Lin, Daniel J Wieczynski and Van M Savage. Interaction dimensionality scales up to generate bimodal consumer-resource size-ratio distributions in ecological communities. (In review)